DMP1 anticorps

N° du produit ABIN7113139

Cet anticorps Lapin Polyclonal détecte spécifiquement DMP1 dans WB, ELISA, IHC et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour DMP1 anticorps (ABIN7113139)

Antigène: DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DMP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-DMP1 anticorps

Fonction: DMP1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DMP1

Immunogen: Dentin matrix acidic phosphoprotein 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur DMP1

Antigène: DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))

Autre désignation: DMP1

Sujet:

Synonyms: Dentin matrix acidic phosphoprotein 1 (DMP-1, Dentin matrix protein 1)|DMP1

Background: Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.

Poids moléculaire: 110 kDa

UniProt: Q13316